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Single-channel recordings of VR1, E636Q, and E648Q activated by capsaicin. I/O patch-clamp records were obtained from oocytes expressing these receptors and exposed to the capsaicin concentrations shown. Channel gating using an expanded time scale is shown below each trace. (A) Representative traces of VR1 (upper) and E636Q (lower) activated by 0.1 μM capsaicin. (B) Representative traces of VR1 (upper) E648Q (lower) channels activated by 0.5 μM capsaicin. Vh = +80 mV.
