Table 1.

Ionic selectivity of VR1 and VR1 mutants

	Na+		K+		Mg2+		Ca2+
	Erev, mV	PNa+/PK+	Erev, mV	PK+/PK+	Erev, mV	PMg2+/PK+	Erev, mV	PCa2+/PK+
VR1	4.2  ± 1.2	1.1	1.3  ± 1.6	1.0	17.9  ± 1.2	1.2	30.0  ± 3.9	2.6
E648Q	−2.5  ± 0.8	0.90	−1.5  ± 0.4	0.94	10.6  ± 0.6	0.71	44.0  ± 1.1	7.9
E636Q	−1.2  ± 0.5	0.94	−0.4  ± 0.9	0.97	15.4  ± 1.1	1.0	54.2  ± 1.5	17.6
D646N	−2.8  ± 1.0	0.89	−2.2  ± 0.6	0.90	10.9  ± 0.8	0.73	26.5  ± 1.1	2.0