Condensation/clumping of nuclear chromatin |
Nuclear chromatin non-specifically degraded |
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Loss of cell–cell contact, cell shrinkage, and fragmentation, with formation of membrane bound processes and vesicles containing fragments of nuclear material or organelles |
Cell volume increases |
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Adjacent cells phagocytose the end product, the apoptotic body |
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Minimal disruption of cell membranes or release of lysosomal enzymes, with consequently little inflammatory reaction |
Cell membrane integrity lost early, release of lysosomal enzymes and subsequent inflammation |
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Organelle structure and function maintained until late into the process |
Organelle structure and function lost early |