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Reduction of exercise capacity with hypoxia. ΔW/W = [maximum workload achieved in normoxia − maximum workload achieved in hypoxia]/maximum workload achieved in normoxia. ΔTlco = differences in lung diffusing capacity for carbon monoxide between the fifth minute of exercise and rest in heart failure patients. Patients with the greatest capability to increase Tlco during exercise are those who show the smallest reduction in exercise capacity in hypoxia.
