Table 1.
Haemodynamic variables at rest and during dobutamine infusion
| Carvedilol, 85 (7.6) mg/day | Metoprolol CR/XL, 160 (16) mg/day | |||||
| Variable | At rest | Dobutamine (5 μg/kg/min) | Dobutamine (15 μg/kg/min) | At rest | Dobutamine (5 μg/kg/min) | Dobutamine (15 μg/kg/min) |
| HR (beats/min) | 57 (2.4) | 57 (3.2) | 56 (2.8) | 57 (2.6) | 60 (3.9) | 76 (5.7)*† |
| SBP (mm Hg) | 122 (6.4) | 132 (8.1)* | 168 (10.3)*† | 123 (6.9) | 128 (7.2) | 130 (6.9) |
| DBP (mm Hg) | 77 (2.1) | 82 (2.2) | 89 (2.6)*† | 78 (3.1) | 78 (2.1) | 77 (2.6) |
| MAP (mm Hg) | 92 (2.5) | 100 (3.1)* | 115 (4.0)*† | 93 (3.7) | 95 (3.4) | 95 (3.8) |
| EF (%) | 31 (3.4) | 35 (3.6) | 36 (3.6) | 31 (2.2) | 35 (2.6) | 35 (2.7) |
| SV (ml) | 58 (4.6) | 72 (6.1)* | 69 (6.2)* | 61 (4.6) | 66 (5.4) | 68 (5.1)* |
| CO (l/min) | 3.4 (0.3) | 4.2 (0.4)* | 3.9 (0.4)* | 3.4 (0.4) | 3.9 (0.5)(p=0.059) | 5.1 (0.4)*† |
| TPR (RU) | 29 (2.2) | 26 (3.4) | 31 (2.5) | 29 (3.7) | 27 (3.1) | 19 (1.7)*† |
Values are mean (SEM).
*p < 0.05 v rest; †p < 0.05 v values during infusion of 5 μg/kg/min dobutamine.
CO, cardiac output; DBP, diastolic blood pressure; EF, ejection fraction; HR, heart rate; MAP, mean arterial pressure; RU, resistance units; SBP, systolic blood pressure; SV, stroke volume; TPR, total peripheral resistance.