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. 2000 Nov 21;97(25):13925–13930. doi: 10.1073/pnas.240269897

Figure 7.

Figure 7

Effects of GABA (10−6 M) in the absence or presence of the GABAA antagonists SR95531 (10−5 M) and bicuculline (10−5 M) on the conversion of [3H]pregnenolone into 17-hydroxypregnenolone and dihydrotestosterone (17OH-Δ5P/5α-DHT; A), dehydroepiandrosterone (DHEA; B), 17-hydroxyprogesterone (17OH-P; C), and progesterone (P; D) by hypothalamic slices. The values were obtained from experiments similar to those presented in Fig. 4. Results are expressed as percentages of the amount of each steroid formed in the absence of drugs. Each value is the mean (±SEM) of four independent experiments. *, P < 0.05; **, P < 0.01; ***, P < 0.001 by one-way ANOVA followed by a post hoc Bonferroni's test; NS, not statistically different.