Table 2.
Actuarial survival and occurrence of valve related events after 10–20 years in patients receiving a Bjork-Shiley or porcine prosthesis
| Aortic valve replacement | Mitral valve replacement | Aortic + mitral valve replacement | |||||||
| 10 Years | 20 Years | p Value* | 10 Years | 20 Years | p Value* | 10 Years | 20 Years | p Value* | |
| Survival | |||||||||
| All survivors | |||||||||
| Bjork-Shiley valve | 64.0 (4.6) | 28.4 (4.4) | 0.57 | 52.7 (4.4) | 22.4 (3.8) | 0.41 | 65.5 (8.8) | 24.1 (8.0) | 0.068 |
| Porcine valve | 65.7 (4.7) | 31.3 (4.7) | 46.5 (4.4) | 18.4 (3.6) | 43.8 (8.8) | 11.7 (5.9) | |||
| Survivors with original prosthesis intact | |||||||||
| Bjork-Shiley valve | 63.1 (4.6) | 27.5 (4.3) | 0.025 | 48.8 (4.4) | 20.8 (3.7) | <0.0001 | 58.6 (9.2) | 20.7 (7.5) | 0.002 |
| Porcine valve | 58.8 (4.9) | 13.7 (3.6) | 31.0 (4.1) | 2.5 (1.4) | 37.5 (8.6) | 3.1 (3.1) | |||
| Survivors without a major event | |||||||||
| Bjork-Shiley valve | 53.8 (4.8) | 15.2 (3.5) | 0.34 | 41.1 (4.3) | 11.9 (3.0) | 0.005 | 48.3 (9.3) | 17.2 (7.0) | 0.018 |
| Porcine valve | 52.0 (5.0) | 8.1 (3.0) | 25.6 (3.8) | 2.5 (1.4) | 37.5 (8.6) | 3.1 (3.1) | |||
| Valve related events | |||||||||
| Reoperation | |||||||||
| Bjork-Shiley valve | 4.2 (2.1) | 7.4 (3.0) | <0.0001 | 8.5 (2.9) | 13.4 (3.9) | <0.0001 | 12.8 (6.9) | 24.2 (9.7) | 0.003 |
| Porcine valve | 11.3 (3.6) | 56.2 (8.4) | 38.6 (5.5) | 77.6 (6.7) | 40.7 (10.6) | 70.9 (11.0) | |||
| Bleeding: all episodes | |||||||||
| Bjork-Shiley valve | 16.3 (4.2) | 61.1 (7.6) | 0.001 | 14.3 (3.9) | 53.1 (8.2) | 0.39 | 14.9 (8.1) | 35.0 (14.5) | 0.71 |
| Porcine valve | 5.9 (2.9) | 42.4 (12.1) | 11.1 (4.3) | 37.2 (10.9) | 0.0 (0.0) | 70.4 (24.4) | |||
| Bleeding: major episodes | |||||||||
| Bjork-Shiley valve | 12.2 (3.7) | 37.8 (7.1) | 0.021 | 11.6 (3.5) | 47.3 (8.5) | 0.044 | 9.5 (6.5) | 22.4 (13.2) | 0.24 |
| Porcine valve | 4.2 (2.4) | 32.0 (12.6) | 6.6 (3.1) | 9.5 (4.1) | 0.0 (0.0) | 70.4 (24.4) | |||
| Embolism: all episodes | |||||||||
| Bjork-Shiley valve | 9.8 (3.2) | 24.0 (6.2) | 0.13 | 29.5 (4.8) | 53.4 (7.1) | 0.32 | 13.3 (7.3) | 13.3 (7.3) | 0.68 |
| Porcine valve | 22.6 (4.9) | 39.2 (8.8) | 28.6 (5.1) | 32.0 (5.9) | 18.7 (8.8) | 18.7 (8.8) | |||
| Embolism: major episodes | |||||||||
| Bjork-Shiley valve | 2.0 (1.4) | 10.3 (4.9) | 0.26 | 14.2 (3.6) | 18.3 (4.5) | 0.19 | 7.9 (5.4) | 7.9 (5.4) | 0.54 |
| Porcine valve | 8.9 (3.3) | 15.4 (7.0) | 10.1 (3.4) | 10.1 (3.4) | 4.6 (4.4) | 4.6 (4.4) | |||
| Endocarditis | |||||||||
| Bjork-Shiley valve | 4.8 (2.4) | 8.3 (4.1) | 0.71 | 2.3 (1.7) | 4.5 (2.7) | 0.38 | 5.8 (5.4) | 13.4 (9.0) | 0.40 |
| Porcine valve | 2.2 (1.6) | 8.7 (6.5) | 7.4 (3.4) | 7.4 (3.4) | 4.6 (4.4) | 28.4 (20.9) | |||
Values are % (mean (SEM)).
*p Values from log rank tests: Bjork-Shiley v porcine valves at 20 years.