Table 2.
Plasma concentrations of lipids, lipoproteins, and Lp(a) at baseline and after two years of treatment with simvastatin (40 mg/day) or atorvastatin (80 mg/day)
| Lipid | Statin | Baseline (n=325 max) | Two years (n=280 max) | Per cent change | p* Value | p† Value |
| Total cholesterol | Simvastatin | 10.27 (2.10) | 6.71 (1.38) | −33.6 | <0.001 | 0.001 |
| Atorvastatin | 9.99 (1.87) | 5.73 (1.31) | −41.8 | <0.001 | ||
| LDL-c | Simvastatin | 8.33 (2.03) | 4.81 (1.38) | −41.2 | <0.001 | 0.001 |
| Atorvastatin | 8.00 (1.83) | 3.88 (1.21) | −50.5 | <0.001 | ||
| HDL-c | Simvastatin | 1.16 (0.28) | 1.30 (0.36) | 13.4 | <0.001 | 0.854 |
| Atorvastatin | 1.18 (0.32) | 1.32 (0.39) | 13.2 | <0.001 | ||
| Triglycerides | Simvastatin | 1.85 (1.34) | 1.41 (0.96) | −17.7 | <0.001 | 0.0023 |
| Atorvastatin | 1.87 (1.09) | 1.23 (0.76) | −29.2 | <0.001 | ||
| Lp(a) | Simvastatin | 531 (184 to 1093) | 417 (137 to 842) | −18.8 | <0.001 | 0.53 |
| Atorvastatin | 327 (168 to 832) | 263 (129 to 707) | −22.1 | <0.001 | ||
Values are means (SD), except for Lp(a) which is in median (interquartile range), in mg/l.
*p Value for relative changes within one treatment group.
†p Value between atorvastatin and simvastatin group.
HDL-c, high density lipoprotein cholesterol; LDL-c, low density lipoprotein cholesterol; Lp(a), lipoprotein(a).