Table 1.
Haemodynamic data, diameter of cardiomyocytes, capillary density, and thiobarbituric reducing substances
| Variable | LETO | LETO+ARB | OLETF | OLETF+ARB |
| Body weight (g) | 489 (22) | 461 (22) | 605 (26)* | 529 (25)† |
| Heart weight (g) | 1.3 (0.1) | 1.2 (0.1) | 1.7 (0.1)* | 1.3 (0.1)† |
| HW/BW (mg/g) | 2.6 (0.1) | 2.6 (0.1) | 2.8 (0.2) | 2.4 (0.1) |
| Heart rate (beats/min) | 412 (37) | 402 (30) | 263 (71)* | 294 (53)* |
| LVPsys (mm Hg) | 96 (4) | 87 (7) | 110 (6)* | 87 (5)† |
| LVEDP (mm Hg) | 6 (2) | 7 (2) | 11 (2)* | 7 (2)† |
| Max dP/dt (mm Hg/s) | 3196 (161) | 2860 (296) | 2390 (1205) | 3240 (746) |
| Min dP/dt (mm Hg/s) | 3492 (286) | 3220 (148) | 2350 (250)* | 3420 (1317)† |
| Diameter (μm) | 18.9 (0.6) | 18.4 (0.4) | 24.3 (0.6)* | 20.1 (1.1)† |
| Density (N/mm2) | 2587 (336) | 2889 (137) | 1768 (227)* | 3055 (151)† |
| TBARS (nM/ml) | 2.9 (0.6) | 2.8 (0.8) | 8.2 (1.5)* | 6.8 (1.2)* |
Values are mean (SD).
*p < 0.05 v LETO; †p < 0.05 v OLETF.
ARB, angiotensin II receptor blockade; BW, body weight; Density, capillary density; dP/dt, rate of change of pressure; diameter, mean diameter of cardiomyocytes; HW, heart weight; LETO, Long-Evans Tokushima Otsuka rats; LVEDP, left ventricular end diastolic pressure; LVPsys, left ventricular systolic pressure; max, maximum. min, minimum; OLETF, Otsuka Long-Evans Tokushima Fatty rats; TBARS, thiobarbituric acid reactive substances.