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Diagram of the functional domains of the β myosin heavy chain (MHC) and the relation of this sarcomeric protein to actin. The 11 mutations analysed in this study were detected in the following functional domains: (A) actin binding site, (B) active site (ATP binding site), (C) essential light chain binding interface, and (D) head–rod junction. Mutations were further subclassified according to the presence (+) or absence (0) of a change in the charge of the substituted amino acid.
