Table 2.
Peak exercise variables after drug and placebo administration
| Treatment | |||||
| Variable | a | b | a+b | p | p Value |
| Exercise time (s) | 730 (335) | 692 (294) | 700 (313) | 712 (300) | 0.97 |
| PV̇o2 (ml/kg/min) | 29.5 (11.1) | 28.9 (10.8) | 29.0 (11.6) | 29.2 (11.4) | 1.0 |
| VE/<V̇co2 slope | 31.8 (7.7) | 31.8 (7.6) | 31.8 (8.1) | 31.8 (8.4) | 1.0 |
| VE (l/min) | 82.0 (23.1) | 76.7 (20.9) | 81.9 (27.7) | 81.0 (24.2) | 0.94 |
| Vt (l) | 2.2 (0.5) | 2.2 (0.5) | 2.2 (0.6) | 2.2 (0.5) | 0.99 |
| Frequency (breaths/min) | 37.4 (6.9) | 36.0 (6.3) | 36.5 (6.6) | 36.5 (7.8) | 0.97 |
| RER | 1.03 (0.03) | 1.01 (0.08) | 1.04 (0.11) | 1.07 (0.07) | <0.02 |
| HR (beats/min) | 151 (19) | 137 (19) | 136 (26) | 151 (21) | <0.05 |
| SBP (mm Hg) | 190 (35) | 186 (31) | 181 (37) | 197 (33) | <0.05 |
| DBP (mm Hg) | 97 (26) | 106 (24) | 98 (26) | 107 (27) | <0.05 |
| Borg/VE slope | 0.13 (0.05) | 0.15 (0.05) | 0.17 (0.15) | 0.20 (0.28) | 0.57 |
| HR/O2 | 3.4 (0.9) | 3.1 (0.9) | 3.0 (0.9) | 3.5 (1.0) | <0.05 |
p Values are for analysis of variance differences between the active treatments and placebo.
a, α blocker; b, β blocker; a+b, α and β blocker; DBP, diastolic blood pressure; p, double placebo;
SBP, systolic blood pressure; Vt, tidal volume.