Table 1 .

Major trials of blood pressure lowering treatment in diabetes

Key trials containing large numbers of subjects with diabetes ALLHAT: chlorthalidone, amlodipine, lisinopril, 33357 subjects, 12063 with diabetes HOT: felodipine, 18790 subjects, 1501 with diabetes LIFE: losartan, atenolol, 9193 subjects, 1195 with diabetes and left ventricular hypertrophy SHEP: 4736 subjects, 583 with diabetes and systolic hypertension Syst-Eur: 4695 subjects, 492 with diabetes and systolic hypertension

Major trials containing only subjects with diabetes IRMA2: irbesartan, 590 subjects with diabetes and microalbuminuria IDNT: irbesartan, 1715 subjects with diabetes and nephropathy RENAAL: losartan, amlodipine, 1513 subjects with diabetes and nephropathy UKPDS/HDS: atenolol, captopril, 1148 subjects with hypertension and newly diagnosed diabetes

See box for explanation of trial acronyms.