Figure 3.

 Domains of the dystrophin protein. The N-terminus contains the primary actin binding sites, whereas the C-terminus contains the β dystroglycan, dystrobrevin, and syntrophin binding sites. The N- and C-terminal domains are connected by 24 spectrin-like repeats, some of which have been shown to bind actin. The four “hinge” regions are shown as blue boxes. The blue horizontal arrows indicate regions of the gene that have been suggested to have a role in function and interaction of dystrophin in the heart.