Figure 1.

 Representative histological features of atherectomy samples from patients with unstable angina pectoris (UAP) and stable angina pectoris (SAP). Foam cells and spindle cells accumulate in an atherectomy sample from a patient with UAP (A). Many of these cells (60% in this field) are positively stained for adrenomedullin (B). Plaque tissue from a patient with SAP is fibrous (C), and immunoreactivity for adrenomedullin is weak in some spindle cells (30% in this field) (D). AM, adrenomedullin; HE, haematoxylin and eosin stain.