Representative immunohistochemical features of atheromatous plaque in a patient with unstable angina pectoris. Many adrenomedullin positive stellate or spindle shaped cells are intimal smooth muscle cells (A, B). Adrenomedullin positive foam cells are macrophages (C, D). In neovascularised microvessels, endothelial cells are immunopositive for adrenomedullin (E, F). AM, adrenomedullin.