Table 2.
Agonist and antagonist properties of selective analogs on cAMP accumulation in sst3 cells
| ID no. | Name | Effect on cAMP accumulation
|
||||
|---|---|---|---|---|---|---|
| Agonists
|
Antagonists
|
|||||
| A
|
B
|
C
|
||||
| EC50, nM | EC50, nM | pKB | IC50, nM | pKi | ||
| 1 | SS-28 | 0.87 ± 0.17 | — | — | — | — |
| 3 | ODT-8 | 1.31 ± 0.13 | — | — | — | — |
| 10 | sst3-ODN-8 | — | 10,230 ± 1,450 | 9.07 | 335 ± 250 | 8.24 |
| 9 | — | 9,410 ± 290 | 9.04 | 430 ± 170 | 8.13 | |
| 8 | — | 980 ± 310 | 8.05 | 960 ± 315 | 7.78 | |
| 6 | — | 840 ± 150 | 7.99 | 1,510 ± 230 | 7.59 | |
| 7 | — | 650 ± 90 | 7.88 | 2,040 ± 720 | 7.46 | |
A, Agonist alone; B, SS-28 versus 10−5 M antagonist; C, antagonist versus 5 × 10−8 M SS-28. All values are mean ± SE (n = 3).