Table 1.

 Patients without, with transient, and with persistent microvascular dysfunction after recanalisation of a chronic total coronary occlusion

	Microvascular dysfunction			p Value
	None	Transient	Persistent
Number of patients	52	29	17
Age (years)	61.6 (9.5)	65.2 (8.2)	65.7 (12.7)	0.16
Prior MI	67%	59%	76%	0.47
Diabetes	13%*	41%	59%	<0.001
Hypertension	71%	90%	76%	0.15
FFR	0.87 (0.07)	0.86 (0.09)	0.87 (0.09)	0.91
Diameter restenosis (%)	49 (19)	47 (21)	43 (17)	0.46
Coronary haemodynamic variables at baseline
Basal APV (cm/s)	25.1 (12.1)**	35.0 (12.6)	40.7 (18.8)	<0.001
Hyperaemic APV (cm/s)	59.8 (26.9)	54.6 (21.5)	58.0 (25.4)	0.72
CFVR	2.44 (0.39)**	1.57 (0.26)	1.46 (0.21)	<0.001
Coronary haemodynamic variables at follow up
Basal APV (cm/s)	21.5 (7.3)†	23.5 (9.9)†††	40.9 (19.7)**	<0.001
Hyperaemic APV (cm/s)	57.1 (19.4)	61.1 (24.9)	66.9 (40.2)	0.39
CFVR	2.78 (0.76)††	2.67 (0.60)†††	1.58 (0.31)**	<0.001
LV function at baseline
LVEF	0.60 (0.17)	0.60 (0.20)	0.52 (0.21)	0.29
WMSI (SD/chord)	−1.86 (1.33)	−1.86 (1.33)	−2.64 (1.27)	0.09
Wall motion extension (chords)	12 (12)	12 (11)	19 (12)	0.08
LV function at follow up
LVEF	0.67 (0.14)†††	0.70 (0.13)††	0.57 (0.24)*†	0.03
WMSI (SD/chord)	−1.28 (1.32)†††	−0.78 (0.95)†††	−2.05 (1.50)*†	0.06
Wall motion extension (chords)	8 (12)††	4 (9)†††	15 (16)*	0.01

Data are mean (SD). p Values represent the results of the ANOVA.

Six patients with reocclusion at follow up are excluded.

Comparison with other groups (post hoc analysis): *p<0.01, **p<0.001; changes within a group during follow up: †p<0.05, ††p<0.005, †††p<0.001.

APV, average peak velocity; CFVR, coronary flow velocity reserve; FFR, fractional flow reserve; LV, left ventricular; LVEF, left ventricular ejection fraction; MI, myocardial infarction; WMSI, wall motion severity index.