Table 3.
Randomised controlled trials of nocturnal respiratory support in patients with OSAHS associated with CHF
Trial | Patient characteristics | Intervention | Duration of treatment | No of patients | Cardiovascular outcomes | ||
CHF cause | NYHA class | Baseline LVEF (%) | |||||
Kaneko et al55 | ICM, DCM | 2.3 | 25.0 | CPAP | 1 month | 24 | 8.8% increase in LVEF, reduced LVESD, reduced heart rate and SBP |
Mansfield et al56 | Not stated | 2.2 | 37.3 | CPAP | 3 months | 55 | 5% increase in LVEF, reduced fatigue and overnight urinary noradrenaline excretion, increased disease mastery and emotional wellbeing (CHFQ) |
CHFQ, Guyatt chronic heart failure questionnaire; CPAP, continuous positive airway pressure; DCM, dilated cardiomyopathy; ICM, ischaemic cardiomyopathy; LVEF, left ventricular ejection fraction; LVESD, left ventricular end systolic dimension; NYHA, New York Heart Association; SBP, systolic blood pressure.