Figure 2.

 Change in exercise (A, B) and haemodynamic parameters (C, D, E, F) from baseline to week 16 of bosentan treatment. Numbers inside bars are mean (SEM). AoP, aortic pressure; METS, metabolic equivalents; NS, not significant; PAP, pulmonary artery pressure; pOx, pulse oximetry; PVo₂, peak oxygen consumption; PVRI, pulmonary vascular resistance index; Qp, pulmonary blood flow; Qs, systemic blood flow; SVRI, systemic vascular resistance index; TPG, transpulmonary pressure gradient. *p < 0.05 v baseline; **p < 0.01 v baseline; ***p < 0.0001 v baseline.