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Binding of mutant Ro proteins to RNA
| Kd xY3 (nM) | Kd pre-5S (nM) | |
|---|---|---|
| wild-type | 5.2 ± 2.5 | 25.0 ± 13.5 |
| Residues that interact with Y RNA | ||
| R146S R149S | 21.9 ± 1.5 | 48.5 ± 14.4 |
| H187S | 153.2 ± 13.6 | 105.2 ± 20.2 |
| R184A | 30.8 ± 5.5 | 187.0 ± 40.2 |
| K108A Q109A R184A | 198.3 ± 10.3 | 135.3 ± 12.2 |
| K136A | 4.8 ± 2.3 | 22.3 ± 7.5 |
| Residues in the central cavity | ||
| K170A R174A | 4.7 ± 2.6 | 179.5 ± 24.1 |
| R255S R283S | 3.4 ± 0.3 | 46.8 ± 0.2 |
| R120S | 5.6 ± 0.7 | 34.1 ± 4.8 |
