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Simulation study design.
| Factor | Number of levels | Description of levels |
|---|---|---|
| reader-sample size | 3 | readers = 3, 5, 10 |
| case-sample size | 4 | cases = 10+/90-, 25+/25-, 50+/50-, 100+/100- |
| AUC | 3 | AUC = .702, .855, .961 |
| variance components | 4 | HH, HL, LH, LL |
Notes: For each factor combination n = 2000 samples are simulated for t = 2 tests, with each reader reading the same cases using each test. “+”= diseased case, “-”= normal case. See Roe and Metz [22] for the definitions of HH, HL, LH, and LL.
