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. Author manuscript; available in PMC: 2007 Jan 12.
Published in final edited form as: Eur J Neurosci. 2006 Sep;24(6):1633–1644. doi: 10.1111/j.1460-9568.2006.05046.x

Fig. 6.

Fig. 6

Cannabinoid-induced increase of histamine release involves activation of CB1-r in the tuberomamillary nuclei (TMN) of freely moving rats. Histamine was measured in 15-min fractions and expressed as a percentage of spontaneous release, calculated as described in Fig. 2. (A and B) The selective CB1-r antagonist AM251 was infused into the TMN 15 min before adding R(+)-methanandamide (mAEA) and maintained in the perfusing medium during administration of the agonist. (C) AM251 was infused in the TMN 15 min before adding AM404 and maintained during administration of the endocannabinoid uptake inhibitor. Bars indicate the period of drug application. Each point represents the means ± SEM of six (A and B) and three experiments (C).