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. Author manuscript; available in PMC: 2007 Aug 17.
Published in final edited form as: Neuron. 2006 Aug 17;51(4):455–466. doi: 10.1016/j.neuron.2006.07.006

Figure 7.

Figure 7

Virally Induced Deletion of CB1 Gene in the Hippocampal Formation Increases the Sensitivity to KA-Induced Seizures

(A and B) Dark-field micrographs showing CB1 mRNA expression in CB1f/f mice 9 weeks after intrahilar injections of AAV-GFP (A) and of AAV-Cre (B), showing the Cre-mediated deletion of CB1 in the hilus of the dentate gyrus and in part of the CA1 and CA3 hippocampal regions. Cx, neocortex; Lh, lateral habenula; bar, 500 μm.

(C) Schematic diagrams showing the approximate extension of Cre-mediated recombination of CB1 (gray shading) in AAV-Cre-injected CB1f/f mice (see Experimental Procedures). Numbers, distance from bregma (Paxinos and Franklin, 2001).

(D) Seizure scoring (30 mg/kg of KA) of AAV-GFP-injected (open circles) and AAV-Cre-injected CB1f/f mice (filled circles). In brackets, number of mice in each experimental group. Data are presented as mean ± SEM. *p < 0.05, by two-way ANOVA.