Table 3.
Comparison of the honeybee catalytic subunits domains with their Drosophila and human homologues
| Percent identity* | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila† | Human† | |||||||||
| Dm PKA-C1 | Dm PKA-C2 | Dm PKA-C3 | PRKCα | PRKACβ | PRKACγ | PRKX | PRKY | ENSG00000177648 | ||
| position‡ | X16969 | X16960 | X16961 | NM_002730 | NM_002731 | NM_002732 | P51817 | O43930 | ||
| N-term | ||||||||||
| Am PKA-C1 | 1–41 | 82.9 | 20 | 14.6 | 51.3 | 46.2 | 41 | 9.8 | 14.6 | ? |
| Am PKA-C2 | 1–36 | 19.4 | 22.2 | 8.3 | 13.9 | 16.7 | 19.4 | 5.6 | 8.3 | ? |
| Am PKA-C3 | 1–19 | 15.8 | 10.5 | 31.6 | 21.1 | 21.1 | 21.1 | 21.1 | 15.8 | ? |
| small Lobe | ||||||||||
| Am PKA-C1 | 42–127 | 93 | 44.2 | 48.8 | 82.6 | 81.4 | 75.6 | 43 | 39.5 | 29.1 |
| Am PKA-C2 | 37–122 | 62.8 | 43 | 41.9 | 61.6 | 65.1 | 53.5 | 38.4 | 34.9 | 25.6 |
| Am PKA-C3 | 20–103 | 45.2 | 33.3 | 52.4 | 46.4 | 44 | 40.5 | 50 | 47.6 | 22.6 |
| large Lobe | ||||||||||
| Am PKA-C1 | 128–302 | 97.7 | 52 | 62.9 | 90.9 | 90.3 | 82.9 | 60 | 57.8 | 56.5 |
| Am PKA-C2 | 123–297 | 68.6 | 52 | 58.3 | 68 | 68 | 64 | 53.1 | 52.4 | 47.2 |
| Am PKA-C3 | 104–278 | 65.1 | 44.6 | 82.9 | 64 | 64 | 62.9 | 76 | 72.1 | 71.4 |
| C-term | ||||||||||
| Am PKA-C1 | 303–353 | 92.2 | 9.8 | 29.4 | 76.5 | 76.5 | 76.5 | 35.3 | – | 35.3 |
| Am PKA-C2 | 298–348 | 45.1 | 5.9 | 29.4 | 43.1 | 43.1 | 43.1 | 25.5 | – | 25.5 |
| Am PKA-C3 | 279–331 | 31.4 | 7.5 | 41.5 | 31.4 | 29.4 | 25.5 | 47.2 | – | 45.3 |
*
The percentage of identical amino acids between the honeybee, the Drosophila and the human subunits with the highest similarity index indicated in bold.
†
The Drosophila and human subunits and their GenBank/EMBL accession numbers.
‡
Location in amino acids of the different honeybee domains within the protein.