Table 4.
Sensitivity, Specificity, Positive Predictive Value, and Negative Predictive Value of Cytology, DIA, and FISH for the Detection of Malignancy by Stricture Classification
| NON PSC PATIENTS | SENSITIVITY (95% CI) | SPECIFICITY (95% CI) | PPV* (95% CI) | NPV≠ (95% CI) |
|---|---|---|---|---|
| PROXIMAL | ||||
| Cytology (positive or suspicious) | 9% (0.01, 0.30) | 100% (0.71, 1) | 100% (0.16, 1) | 37% (0.20, 0.56) |
| Positive | 4% (0.001, 0.24) | 100% (0.71, 1) | 100% (-) | 35% (0.19, 0.55) |
| Suspicious | 4% (0.001, 0.24) | 100% (0.71, 1) | 100% (-) | 35% (0.19, 0.55) |
| DIA (aneuploid or tetraploid) | 30% (0.12, 0.54) | 90% (0.55, 1) | 86% (0.42, 1) | 39% (0.20, 0.61) |
| Tetraploid | 5% (0.001, 0.25) | 100% (0.69, 1) | 100% (-) | 34% (0.18, 0.54) |
| Aneuploid | 25% (0.09, 0.49) | 90% (0.55, 1) | 83% (0.36, 0.99) | 37% (0.19, 0.59) |
| FISH (polysomy or trisomy) | 63% (0.38, 0.84) | 100% (0.66, 1) | 100% (0.73, 1) | 56% (0.30, 0.80) |
| FISH polysomy | 31% (0.12, 0.56) | 100% (0.66, 1) | 100% (0.54, 1) | 41% (0.21, 0.64) |
| FISH trisomy | 31% (0.12, 0.56) | 100% (0.66, 1) | 100% (0.54, 1) | 41% (0.21, 0.64) |
| DISTAL | ||||
| Cytology (positive or suspicious) | 41% (0.29, 0.54) | 96% (0.86, 0.99) | 93% (0.77, 0.99) | 54% (0.43, 0.65) |
| Positive | 20% (0.11, 0.31) | 100% (0.93, 1) | 100% (0.75, 1) | 47% (0.37, 0.58) |
| Suspicious | 21% (0.12, 0.33) | 96% (0.86, 0.99) | 87% (0.62, 0.98) | 47% (0.37, 0.57) |
| DIA (aneuploid or tetraploid) | 49% (0.36, 0.62) | 98% (0.88, 1) | 97% (0.84, 1) | 57% (0.45, 0.69) |
| Tetraploid | 16% (0.08, 0.27) | 100% (0.92, 1) | 100% (0.69, 1) | 45% (0.35, 0.56) |
| Aneuploid | 33% (0.22, 0.46) | 98% (0.88, 1) | 95% (0.77, 1) | 50% (0.39, 0.62) |
| FISH (polysomy or trisomy) | 59% (0.46, 0.71) | 92% (0.80, 0.98) | 90% (0.77, 0.97) | 63% (0.50, 0.74) |
| FISH polysomy | 48% (0.35, 0.60) | 100% (0.93, 1) | 100% (0.88, 1) | 59% (0.48, 0.70) |
| FISH trisomy | 11% (0.04, 0.21) | 92% (0.80, 0.98) | 64% (0.31, 0.89) | 44% (0.34, 0.54) |
| PSC PATIENTS | ||||
| Cytology (positive or suspicious) | 41% (0.18, 0.67) | 97% (0.90, 1) | 78% (0.40, 0.97) | 87% (0.77, 0.93) |
| Positive | 18% (0.04, 0.43) | 100% (0.95, 1) | 100% (0.29, 1) | 83% (0.73, 0.90) |
| Suspicious | 23% (0.07, 0.50) | 97% (0.90, 1) | 67% (0.22, 0.96) | 83% (0.73, 0.91) |
| DIA (aneuploid or tetraploid) | 43% (0.18, 0.71) | 87% (0.76, 0.94) | 43% (0.18, 0.71) | 87% (0.76, 0.94) |
| Tetraploid | 14% (0.02, 0.43) | 95% (0.86, 0.99) | 40% (0.05, 0.85) | 83% (0.72, 0.91) |
| Aneuploid | 28% (0.08, 0.58) | 92% (0.82, 0.97) | 44% (0.14, 0.79) | 85% (0.74, 0.92) |
| FISH (polysomy or trisomy 7or 3) | 70% (0.44, 0.90) | 86% (0.75, 0.93) | 57% (0.34, 0.78) | 92% (0.82, 0.97) |
| FISH polysomy | 47% (0.23, 0.72) | 100% (0.94, 1) | 100% (0.63, 1) | 88% (0.78, 0.94) |
| FISH trisomy | 23% (0.07, 0.50) | 86% (0.75, 0.93) | 31% (0.09, 0.61) | 81% (0.69, 0.89) |
*
PPV= positive predictive value
CI denotes 95% confidence interval
≠
NPV= negative predictive value
(-) = insufficient number of patients to calculate 95% CI