Table 5.
Sensitivity, Specificity, Positive Predictive Value, and Negative Predictive Value of Cytology, DIA, and FISH for the Detection of Malignancy by Stricture Classification when Cytology is neither positive nor suspicious
| NON PSC PATIENTS | SENSITIVITY (95% CI) | SPECIFICITY (95% CI) | PPV* (95% CI) | NPV≠ (95% CI) |
|---|---|---|---|---|
| PROXIMAL | ||||
| DIA (tetraploid or aneuploid) | 28% (0.1, 0.53) | 90% (0.55, 1) | 83% (0.36, 0.99) | 41% (0.21, 0.64) |
| Tetraploid | 5% (0.001, 0.27) | 100% (0.69, 1) | 100% (-) | 37% (0.19, 0.58) |
| Aneuploid | 22% (0.06, 0.48) | 90% (0.55, 1) | 80% (0.28, 0.99) | 39% (0.20, 0.61) |
| FISH (polysomy or trisomy 7 or 3) | 59% (0.33, 0.81) | 100% (0.66, 1) | 100% (0.69, 1) | 56% (0.30, 0.80) |
| FISH polysomy | 23% (0.07, 0.50) | 100% (0.66, 1) | 100% (0.40, 1) | 41%(0.21, 0.64) |
| FISH trisomy (7 or 3) | 35% (0.14, 0.62) | 100% (0.66, 1) | 100% (0.54, 1) | 45% (0.23, 0.68) |
| FISH (polysomy or trisomy) and DIA (aneuploid or tetraploid) | 23% (0.07, 0.50) | 100% (0.66, 1) | 100% (0.40, 1) | 41% (0.21, 0.64) |
| FISH (polysomy or trisomy) or DIA (aneuploid or tetraploid) | 65% (0.38, 0.86) | 89% (0.52, 1) | 92% (0.61, 1) | 57% (0.29, 0.82) |
| DISTAL | ||||
| DIA (aneuploid or tetraploid) | 25% (0.12, 0.42) | 98% (0.87, 0.99) | 90% (0.55, 1) | 60% (0.48, 0.72) |
| Tetraploid | 5% (0.007, 0.19) | 100% (0.91, 1) | 100% (0.16, 1) | 55% (0.43, 0.67) |
| Aneuploid | 19% (0.08, 0.36) | 98% (0.87, 0.99) | 87% (0.47, 1) | 58% (0.46, 0.70) |
| FISH (polysomy or trisomy 7 or 3) | 35% (0.20, 0.52) | 93% (0.82, 0.99) | 81% (0.54, 0.96) | 64% (0.51, 0.75) |
| FISH polysomy | 22% (0.1, 0.38) | 100% (0.92, 1) | 100% (0.63, 1) | 61% (0.49, 0.72) |
| FISH trisomy (7 or 3) | 13% (0.04, 0.29) | 93% (0.82, 0.99) | 62% (0.24, 0.91) | 57% (0.45, 0.69) |
| FISH (polysomy or trisomy) and DIA (aneuploid or tetraploid) | 15% (0.05, 0.31) | 98% (0.87, 1) | 83% (0.36, 0.99) | 58% (0.46, 0.70) |
| FISH (polysomy or trisomy) or DIA (aneuploid or tetraploid) | 48% (0.31, 0.66) | 93% (0.80, 0.98) | 85% (0.62, 0.97) | 68% (0.55, 0.80) |
| PSC PATIENTS | ||||
| DIA (aneuploid or tetraploid) | 14% (0.004, 0.58) | 88% (0.77, 0.95) | 12% (0.003, 0.53) | 90% (0.79, 0.96) |
| Tetraploid | 0 (0, 0.41) | 97% (0.88, 0.99) | 0 (0, 0.84) | 89% (0.79, 0.95) |
| Aneuploid | 14% (0.004, 0.58) | 91% (0.81, 0.97) | 17% (0.004, 0.64) | 90% (0.79, 0.96) |
| FISH (polysomy or trisomy 7 or 3) | 60% (0.26, 0.88) | 87% (0.76, 0.94) | 43% (0.18, 0.71) | 93% (0.83, 0.98) |
| FISH polysomy | 20% (0.02, 0.56) | 100% (0.94, 1) | 100% (0.16, 1) | 88% (0.79, 0.95) |
| FISH trisomy (7 or 3) | 40% (0.12, 0.74) | 87% (0.76, 0.94) | 33% (0.1, 0.65) | 90% (0.79, 0.96) |
| FISH (polysomy or trisomy) and DIA (aneuploid or tetraploid) | 14% (0.004, 0.58) | 98% (0.91, 1) | 50% (0.01, 0.99) | 90% (0.80, 0.96) |
| FISH (polysomy or trisomy) or DIA (aneuploid or tetraploid) | 67% (0.30, 0.92) | 75% (0.62, 0.86) | 30% (0.12, 0.54) | 93% (0.82, 0.99) |
*
PPV- positive predictive value
≠
NPV – negative predictive value
CI denotes 95% confidence interval
(-) = insufficient number of patients to calculate 95% CI