Table 1.

Immunohistochemical analysis of BMP expression in 47 osteosarcomas

Antibody	++	+	−	Total BMP positive (%)
BMP-2/4	4	24	19	28 (59)
BMP-3	4	20	23	24 (51)
BMP-5	19	22	6	41 (87)
BMP-6	13	18	16	31 (68)
BMP-7	27	16	4	43 (91)
BMP-8	15	27	5	42 (90)

Immunostaining results are graded as follows: ++, 50–95% of tumour cells positive; +, 10–49% of tumour cells positive; −, less than 10% of tumour cells positive or no visible staining.

BMP, bone morphogenetic protein.