Table 2.

Demographic details of patients, risk factors for their OSCCs, and TP53 gene and p53 protein alterations

					Sequence of exons 5–8 of the TP53 gene
Tn	Sex/age	Smoking habits (cig/day)	Alcohol habits (U/day)	p53 IHC	Mutation	Exon	Codon	AA change
T1	M/81	NS	<2	Negative	CGA>TGA	6	213	Arg→Stop
T4	F/55	>20	>4	Negative	No	–	–	–
T12	F/79	NS	<2	Negative	No	–	–	–
T17	M/68	<10	>4	Negative	Deletion 2bp	5	145	Frameshift
T19	M/67	10–20	2–4	Negative	CGA>TGA	6	213	Arg→Stop
T27	F/63	>20	>4	<25%	CGA>CGG*	6*	213*	Arg→Arg*
T31	F/81	NS	<2	<25%	No	–	–	–
T38	F/56	unk	unk	25–50%	CGC>CAC	5	175	Arg→His
T46	M/45	unk	unk	>75%	CAT>CGT	6	193	His→Arg
T52	M/39	>20	2–4	>75%	TTT>CTT	5	134	Phe→Leu

*Compatible with well described p53 polymorphism.

AA, amino acid; cig, cigarettes; IHC, immunohistochemistry; NS, non-smoker; OSCC, oral squamous cell carcinoma; unk, unknown; U, units of alcoholic beverage.