Table 2.

Frequency of APC mutation and budding in colorectal cancers stratified as MSI-H, HNPCC, MSI-L, and MSS

Category	APC mutation	Budding
A MSI-H (n=21)	1 (4.8%)	0 (0%)
B HNPCC (n=15)	4 (26.7%)	3 (20%)
C MSI-L (n=43)	14 (32.6%)	18 (41.9%)
D MSS (n=16)	6 (37.5%)	9 (56.2%)

APC mutation (χ² analysis): A v C, p=0.01; A v D, p=0.01.

Budding (χ² analysis): A v C, p <0.001; A v D, p <0.001, B v D, p=0.04.

HNPCC, hereditary non-polyposis colorectal cancer; MSI-H, high degree of microsatellite instability; MSI-L, low degree of microsatellite instability; MSS, microsatellite stable.