Table 2.

Relations between nuclear p21^WAF1 expression and p53, AP-2, cell proliferation (Ki-67), and clinicopathological variables

		p21WAF1 expression
Variable	Sample n	Low <5%	High ≥5%	χ2	df	p Value
Stage				0.3	2	0.844
I	163	62	38
II	212	61	39
III	38	66	34
Lymph node status				3.1	1	0.079
Negative	247	58	42
Positive	166	67	33
Histological type				7.4	2	0.025
Ductal	273	59	41
Lobular	65	77	23
Other	82	59	41
Histological grade				8.1	2	0.017
I	108	73	27
II	192	57	43
III	120	60	40
ER status				3.1	1	0.077
Positive	323	59	41
Negative	95	70	30
PR status				1.6	1	0.205
Positive	261	59	41
Negative	157	66	34
Recurrence at 5 years				0.6	1	0.441
No	344	61	39
Yes	76	66	34
Nuclear p53				4.2	1	0.041
Low <10%	225	66	34
High ≥10%	193	57	43
Nuclear AP-2				<0.1	1	0.785
Low <80%	211	62	38
High ≥80%	204	61	39
Cell proliferation				2.5	1	0.113
Low <20%	230	65	35
High ≥20%	184	58	42

For p21^WAF1 expression the median value was used as the cut off value.

AP-2, activator protein 2; df, degrees of freedom; ER, oestrogen receptor; PR, progesterone receptor.