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. 2003 Mar;56(3):214–220. doi: 10.1136/jcp.56.3.214

Table 3.

Immunohistochemical and significant clinicopathological variables of breast cancer related and recurrence free survival in univariate survival analysis

Surviving breast cancer at 5 years Recurrence free at 5 years
Variable n % p Value n % p Value
Stage <0.001 <0.001
    I 163 92 163 87
    II 212 86 212 77
    III 38 54 38 54
Lymph node status <0.001 <0.001
    Negative 247 92 247 86
    Positive 166 77 166 68
Histological grade 0.043 0.071
    I 108 92 108 85
    II 192 85 192 78
    III 120 81 120 74
ER status <0.001 0.124
    Positive 323 89 323 80
    Negative 95 72 95 74
PR status 0.001 0.183
    Positive 261 89 261 80
    Negative 157 78 157 76
Nuclear p21WAF1 0.398 0.388
    Low <5% 260 84 260 78
    High ≥5% 160 87 160 80
Nuclear p53 0.837 0.678
    Low <10% 225 86 225 79
    High ≥10% 193 84 193 78
Combined p21/p53 0.461 0.782
    p21+/p53+ 84 84 84 80
    p21+/p53− 76 91 76 79
    p21−/p53+ 109 85 109 76
    p21−/p53− 149 83 149 79
Cell proliferation <0.001 <0.001
    Low <20% 230 93 230 89
    High ≥20% 184 75 184 64

ER, oestrogen receptor; PR, progesterone receptor.