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. 2003 Jul;56(7):491–496. doi: 10.1136/jcp.56.7.491

Table 1.

ING1 gene structural mutations in human cancers

Codon Position Mutation Change Coding Rate Origin Tissue type First author (year)
89 N-terminus Silent G/A Val Skmel-110 Melanoma Campos (2002)
95 N-terminus Missense CCC/TCC Pro/Ser 1/422 Patient Breast and ovarian ca Toyama (1999)
101 N-terminus Silent C/T Asp Skmel-110 Melanoma Campos (2002)
166 C-terminus Silent G/A Arg 1/442 Patient Breast and ovarian ca Toyama (1999)
172 C-terminus Missense GAG/AAG Glu/Lys HCT116 Colon carcinoma Oki (1999), Ito (2002)
173 C-terminus Silent G/A Ser 3/23 Patient Head and neck SCC Gunduz (2000)
188 NLS/NTS Silent G/A Ser 18/442 Patient Breast and ovarian ca Toyama (1999)
188 NLS/NTS Silent G/A Ser MKN28 Gastric carcinoma Oki (1999)
188 NLS/NTS Silent G/A Ser MKN45 Gastric carcinoma Oki (1999)
188 NLS/NTS Silent G/A Ser 14/71 Patient Oral SCC Krishnamurthy (2001)
192 C-terminus Missense GCC/GAC Ala/Asp 1/23 Patient Head and neck SCC Gunduz (2000)
214 PHD Missense GCG/GAG Ala/Glu 1/31 Patient ESCC Chen (2001)
215 PHD Missense TGC/TCC Cys/Ser 1/23 Patient Head and neck SCC Gunduz (2000)
216 PHD Missense AAC/AGC Asx/Ser 1/23 Patient Head and neck SCC Gunduz (2000)
219 PHD Silent C/T Pro 1/31 Patient Oesophageal SCC Chen (2001)
223 PHD Silent C/T Asn 1/31 Patient Oesophageal SCC Chen (2001)
228 PHD Silent T/C Cys 1/442 Patient Breast and ovarian ca Toyama (1999)
233 PHD Missense GTC/ATC Val/Leu 1/31 Patient Oesophageal SCC Chen (2001)
236 PHD Missense GGG/GTG Gly/Val 1/31 Patient Oesophageal SCC Chen (2001)
239 PHD Silent G/C Ser Skmel-24 Melanoma Campos (2002)
244 PHD Silent T/C Asn Skmel-24 Melanoma Campos (2002)
247 PHD Silent C/A Pro Skmel-24 Melanoma Campos (2002)
253 PHD Silent T/C Cys Skmel-24 Melanoma Campos (2002)
257 PHD Silent G/T Arg Skmel-24 Melanoma Campos (2002)
260 PHD Missense AAC/AGC Asn/Ser Skmel-24 Melanoma Campos (2002)
270 PHD Silent A/G Lys Skmel-24 Melanoma Campos (2002)
270 PHD Missense AAG/AAT Lys/Asn 1/31 Patient Oesophageal SCC Chen (2001)
272 PHD Silent A/G Lys Skmel-24 Melanoma Campos (2002)

ca, carcinoma; NLS, nuclear localisation signal; NTS, nucleolar targeting sequence; PHD, plant homeodomain; SCC, squamous cell carcinoma.