Table 1.
Hemodynamic variables and physiological parameters
| Parameter | Sham | AMI + saline | AMI + rAAV–GFP | AMI + rAAV–CD151 |
|---|---|---|---|---|
| n | 8 | 6 | 6 | 7 |
| BW, g | 341.38 ± 11.61 | 344.83 ± 11.77 | 353.67 ± 19.44 | 343 ± 17.18 |
| LVW, mg | 721.3 ± 22.90 | 755 ± 15.17 | 746.7 ± 45.46 | 717.14 ± 22.15 |
| HW, mg | 853.25 ± 39.88 | 1075 ± 94.18 | 1086.67 ± 127.23 | 942.57 ± 56.21 |
| LVW/BW, mg/g | 2.11 ± 0.07 | 2.14 ± 0.05 | 2.13 ± 0.11 | 2.09 ± 0.07 |
| HW/BW, mg/g | 2.50 ± 0.11 | 3.08 ± 0.29* | 3.07 ± 0.25* | 2.75 ± 0.08† |
| LVEDP, mmHg | 3.51 ± 0.61 | 23.27 ± 2.42* | 23.3 ± 3.26* | 4.89 ± 8.81† |
| LVESP, mmHg | 135.66 ± 2.00 | 113.5 ± 3.54* | 115.20 ± 2.26* | 126.11 ± 2.64† |
| +dp/dtmax, mmHg/s | 7400.75 ± 129.27 | 3522.33 ± 307.66* | 3713 ± 195.53* | 6073.29 ± 407.96† |
| −dp/dtmax, mmHg/s | 4417.13 ± 142.75 | 3764.83 ± 99.91* | 3710.83 ± 170.10* | 3992.29 ± 120.60† |
At 4 weeks after coronary artery ligation, hemodynamic variables were monitored using a catheter tip manometer advanced from the right carotid artery via the aortic arch into the left ventricle at the end of the experiment. Data represent means ± SEM. BW, body weight; HW, heart weight; LVW, left ventricular weight; LVEDP, left ventricle end–diastolic pressure; LVESP, left ventricle end–systolic pressure; ±dp/dtmax, maximal rate of increase and decline in left ventricular pressure.
*
P < 0. 05 vs. sham;
†
P < 0.05 vs. sham, AMI + saline, and AMI + rAAV–GFP.