Table 1.
Interpretation and diagnostic decision making for lesions 1 and 2
| Pathologist | Time until diagnosis (sec) | Abnormal maturation* | Nuclear atypia* | Mitotic activity* | Basement membrane | Order of criteria | Diagnosis | |
| Lesion 1 | 1 | 16 | Up to 2/3 | Up to 2/3 | Up to 2/3 | Intact | B | CIN 2 |
| 2† | 45 | Up to 2/3 | Up to 2/3 | Up to 2/3 | Intact | B | CIN 3 | |
| 3 | 20 | Up to 3/3 | Up to 2/3 | Up to 2/3 | Intact | A | CIN 3 | |
| 4 | 7 | Up to 3/3 | Up to 3/3 | Up to 2/3 | Intact | D | CIN 3 | |
| 5† | 28 | Up to 3/3 | Up to 2/3 | Up to 2/3 | Intact | A | CIN 2 | |
| Lesion 2 | 1 | 18 | Up to 2/3 | Up to 3/3 | Up to 1/3 | Intact | C | CIN 3 |
| 2 | 45 | Up to 1/3 | Up to 1/3 | Up to 1/3 | Intact | C | CIN 1 | |
| 3 | 32 | Up to 2/3 | Up to 2/3 | Up to 1/3 | Intact | A | CIN 2 | |
| 4 | 26 | Up to 3/3 | Up to 3/3 | Up to 1/3 | Intact | C | CIN 3 | |
| 5† | 31 | Up to 1/3 | Up to 3/3 | Up to 1/3 | Intact | A | CIN 1 |
Order of criteria: A, proliferation→nuclear atypia→mitotic activity→basement membrane; B, proliferation→mitotic activity→nuclear atypia→basement membrane; C, nuclear atypia→proliferation→mitotic activity→basement membrane; D, nuclear atypia→mitotic activity→proliferation→basement membrane.
*Up to X/3 of the epithelium involved; †diagnosis in discordance with Armed Forces Institute of Pathology criteria.
CIN, cervical intraepithelial neoplasia.