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Tracking bone marrow by sex mismatched bone marrow transplantation. Male to female transplantation is useful for detecting transdifferentiation by detection of the Y chromosome. However, cell fusion may be missed because not all chromosomes might be visible in the tissue section. Female to male transplantation is more suitable for detecting fusion events; marked bone marrow derived parenchymal cells with a Y chromosome have definitely been formed by fusion with host cells.
