Table 1.

Systemic mastocytosis with an associated clonal haematological non-mast cell disease (SM-AHNMD): list of diagnoses of the AHNMDs and biological features of neoplastic cells

AHNMD	No. of cases	C-KIT mutation (N)	CD25+
MDS: RARS	1	D816V (1)	1/1
MDS: RAEB1	1	D816V (1)	1/1
MDS/MPS (CMML)	7	D816V (5)	7/7
		D816Y (1)
		wt (1)
MPS: PVR	1	wt (1)	1/1
MPS: CIM	2	D816V (2)	2/2
AML M1	1	No amplification	1/1
AML M2	2	D816V (2)	2/2
AML M4	1	wt (1)	1/1
Plasma cell myeloma	2	D816V (1)	2/2
		D816Y (1)
NC (probably MDS/MPS)	2	D816V (2)	2/2
Total	20	16	20

AML, acute myeloid leukaemia; CIM, chronic idiopathic myelofibrosis; CMML, chronic myelomonocytic leukaemia; D816V, Asp816→Val; D816Y, Asp816→Tyr; MDS/MPS, myelodysplastic/myeloproliferative syndrome; NC, not classifiable; PVR, polycythaemia vera rubra; RAEB1, refractory anaemia with excess of blasts (5–10%); RARS, refractory anaemia with ringed sideroblasts; wt, wild-type.