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. 2004 Sep;57(9):973–979. doi: 10.1136/jcp.2003.015875

Figure 3.

Figure 3

 Lamina propria counts of IgA, IgM, and IgG producing cells (mean ±SEM) in colonic biopsies from control patients (group A), patients with Clostridium difficile associated diarrhoea (CDAD) and absent/minimal inflammation (group B), and patients with pseudomembranous colitis (PMC). Biopsies from patients with PMC were obtained from mucosa adjacent to pseudomembrane (group C) and mucosa with overlying pseudomembrane and with a “volcano” lesion (group D). Compared with controls (group A), IgA producing cells were reduced in biopsies from patients with CDAD and absent/minimal inflammation (group B) (*p < 0.05), and those obtained from patients with PMC (groups C and D; +p < 0.001 for both). IgA producing cells were also significantly lower in group C and D biopsies, when compared with those in group B (#p < 0.01 for both comparisons). Compared with the other groups, there was a significant reduction in the number of IgM producing cells in group D biopsies (*p < 0.05). In contrast, IgG producing cells were significantly increased in group B and C biopsies (both *p < 0.05).