Loss of heterozygosity (LOH) at the nm23-H1 gene microsatellite locus in sporadic colon adenocarcinomas. N, normal; T, tumour; lanes 1 and 4, homozygous (not informative); lanes 2 and 5, heterozygous (informative) without LOH; lanes 3 and 6, heterozygous with LOH; lane M, DNA marker pBR 322 DNA MspI digest. The gel is silver stained.