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The results of histopathological analysis. (A) Normal lung parenchyma from untreated mice. (B) Pronounced thickening of the alveolar septa, collapse of alveolar spaces, large numbers of lymphocytes accumulated in the alveolar walls, and proliferation of fibroblasts at day 14 after the bleomycin instillation in wild-type mice, and (C) attenuated lung inflammation and fibrosis in perforin knockout mice 14 days after bleomycin instillation.
