Table 2.
Studies assessing B cell clonality in Hashimoto’s thyroiditis
| First author | Technique | No. of cases | Clonality | Year/Ref |
| Ben-Ezra | SBH | 4 | No | 1988/13 |
| Knowles | SBH | 1 | Yes (1/1) | 1989/7 |
| Katzin | SBH | 6 | No | 1989/23 |
| Hyjek | IHC | 21 | Yes* (5/21) | 1988/10 |
| Matsubayashi | Flow cytometry and IHC | 5 | Yes (5/5) | 1990/12 |
| Wacker | PCR (TGGE) | 18 | Yes (4/18) | 1994/24 |
| Tiemann | PCR (TGGE) | 40 | Yes (8/40) | 1996/25 |
| Hsi | PCR and IHC | 40 | No | 1998/14 |
| Present study | PCR and sequencing | 10 | Yes (3/10) |
*Initially diagnosed as Hashimoto’s thyroiditis but revised to malignant lymphoma in view of clonal population. However, the histology of low grade mucosa associate lymphoid tissue lymphoma was noticed in these cases.
IHC, immunohistochemistry; PCR, polymerase chain reaction; SBH, Southern blot hybridisation; TGGE, temperature gradient gel electrophoresis.