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(A) LYVE-1 immunostaining at the invading front of an endometrial adenocarcinoma. Note the positive staining of lymphatics (large black arrows), whereas adjacent blood vessels are negative (white arrows). (B) CD31 immunostaining of the same area exhibiting blood vessel (large black arrows) but not lymphatic vessel (white arrows) reactivity. (C) LYVE-1/MIB1 double immunostaining of the same area. Note MIB-1 stained nuclei (small black arrows) of both lymphatic and vascular endothelium.
