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Kaplan–Meier recurrence free survival curves for 166 patients with breast cancer. (A) Recurrence free survival curves for patients with (⩾ 1%) (n = 66) or without hypoxia inducible factor 1α (HIF-1α) expression (n = 100); log rank p value, 0.01. (B) Recurrence free survival curves for patients without (< 1%) HIF-1α expression (n = 100) versus diffuse HIF-1α expression (n = 51) or necrosis related HIF-1α expression (n = 15); global log rank p value, 0.02.
