Table 2.

 Associations between HIF-1α staining pattern, grade, and expression of CA IX and GLUT-1 for HIF-1α positive breast cancer cases (n = 88)

	n	HIF-1α staining pattern*		p Value (χ2)
		Diffuse	Necrotic
Grade
I	15	13	2
II	30	25	5
III	43	23	20	0.007
CA IX
Negative	67	55	12
Positive	21	6	15	<0.001
GLUT-1
Negative	46	41	5
Positive	42	20	22	<0.001

*One case, which was grouped with the perinecrotic cases, showed both diffuse and perinecrotic expression.

CA IX, carbonic anhydrase IX; GLUT-1, glucose transporter 1; HIF-1α, hypoxia inducible factor 1α.