Table 2.
Antimicrobial activity of two-disulfide analogs in low-salt conditions
| Organism | MIC, μM
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Kalata
|
CirA
|
CirB
|
Cpt
|
||||||
| 8a | 12 | 13 | 10a | 10b | 10c | 11a | 11b | 11c | |
| E. coli | >500 | >500 | >500 | 0.33 | 0.45 | 0.57 | 2.80 | 1.55 | 0.98 |
| Pse. aeruginosa | >500 | >500 | >500 | 48.0 | 50.2 | 50.2 | 17.5 | 48.0 | 13.5 |
| Pr. vulgaris | 48.5 | NT | 45.5 | 14.8 | 48.0 | 18.2 | 15.6 | 18.4 | 14.8 |
| K. oxytoca | 44.6 | 56.5 | NT | 10.5 | 20.4 | 18.6 | 5.60 | 5.20 | 17.4 |
| S. aureus | 0.29 | 33.5 | 0.21 | 48.0 | 13.5 | 29.5 | 7.90 | 48.0 | 13.5 |
| M. luteus | 14.2 | >500 | >500 | >500 | >500 | >500 | 8.0 | 48.0 | 13.2 |
| C. albicans | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 |
| C. kefyr | 19.2 | 48.0 | 51.4 | 29.0 | 18.5 | 48.0 | 48.0 | 106 | 29.0 |
| C. tropicalis | >500 | >500 | 49.8 | >500 | >500 | >500 | >500 | >500 | >500 |
All peptides also were tested in high-salt conditions (100 mM NaCl) and were found to be inactive at MIC >500 μM except CirB 10c, Cpt 11c, and Cpt 11b against K. oxytoca and C. kefyr with MIC of 29.0–56.5 μM. NT, not tested.