Figure 1.

 Clinical and virological response to combination treatment with interferon α and interferon γ. Biweekly energy level, the sum of daily energy index (0–10) for two weeks, was recorded by two patients (A, B) before, during, and after a one month treatment with interferon α (Pegasys 180 μg; once/week) and interferon γ (100 μg; three times/week). An enteroviral RNA assay of the peripheral blood leucocytes were performed before, during, and after the treatment, and expressed as + or − on the top of the graph. The arrow indicates vigorous exercise after treatment. The graphs show clearance of circulating viral RNA after antiviral treatment, and an association between vigorous exercise, reappearance of circulating viral RNA, and decreased energy.