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. 2007 Jan 12;401(Pt 3):679–688. doi: 10.1042/BJ20060555

Figure 1. Domain and sequence comparison of CENTG1.

Figure 1

(A) Domain architecture of the centaurins and small GTPases. PIKE isoform-A or CENTG1 is shown in comparison with long isoform PIKE-L and small GTPases. The proline-rich domain present only in PIKE-L is shown in black rectangles at the N-terminus. The GLDs of CENTG1 and PIKE-L, and GTPase domain of a small GTPase are shown in light grey. The PH and Arf-GAP domains are indicated. Two ankyrin repeats in the C-terminus are shown as black dot-filled boxes. (B) Sequence alignment of human CENTG with small GTPases. ClustalW-based sequence alignment of CENTG1 (gi:6176569), CENTG2 (gi:51338837) and CENTG3 (gi:16799069) with the small GTPases c-H-Ras (gi:231061) and Rab9A (gi:55670684), with editing to reflect the structural superimposition. Identical amino acids are indicated by an asterisk (*). Highly conserved small GTPase functional loops, G1–G5, are highlighted in grey. The secondary-structure depiction beneath the sequences is according to the CENTG1 GLD structure determined here (PDB code 2BMJ). α-Helices are represented as rectangles and β-sheets as arrows.