Table 3.
Chronic fatigue syndrome associated genes: chromosomal location, expression, subcellular localisation, and function
| GenBank accession number | Gene name (mRNA) | Gene symbol* | Chromosomal location | Expression | Subcellular localisation | Gene function |
| NM_020325 | ATP binding cassette, subfamily D (ALD), member 4, tv-4 | ABCD4 | 14q24.3 | Ubiquitous | Peroxisomal membrane | ALDP expression |
| NM_002741 | Protein kinase C-like 1 | PRKCL1 | 19p13.1–p12 | Ubiquitous | Cytoplasm | Regulation of cell motility |
| NM_021134 | Mitochondrial ribosomal protein L23 | MRPL23 | 11p15.5 | Widely expressed | Mitochondrial matrix | Protein biosynthesis |
| NM_001558 | Interleukin 10 receptor α | IL10RA | 11q23.3 | – | Unknown | Cytokine signalling |
| NM_006110 | CD2 antigen (cytoplasmic tail) binding protein 2 | CD2BP2 | 16p12.1 | – | Unknown | – |
| NM_000177 | Gelsolin (amyloidosis, Finnish type) | GSN | 9q33.3 | – | Unknown | Severing and capping of actin |
| NM_006702 | Neuropathy target esterase | NTE | 19p13.3–p13.2 | Nervous system | Plasma membrane | Neurodegenerative disease |
| NM_002696 | Polymerase (RNA) II (DNA directed) polypeptide G | POLR2G | 11q13.1 | Nervous system | Nucleus | Transcription from Pol II |
| NM_004813 | Peroxisomal biogenesis factor 16, tv-1 | PEX16 | 11p11.11 | – | Peroxisomal membrane | Peroxisomal biogenesis |
| NM_015636 | Eukaryotic translation initiation factor 2B, subunit 4δ, tv-1 | EIF2B4 | 2p23.3 | Ubiquitous | Mitochondrion | Initiation of translation |
| NM_004953 | Eukaryotic translation initiation factor 4γ, 1, tv-5 | EIF4G1 | 3q27–qter | Ubiquitous | Mitochondrion | Initiation of translation |
| NM_016476 | APC11 anaphase promoting complex subunit 11 homologue | ANAPC11 | 17q25.3 | Brain, heart, pancreas, lung | Nucleus | Ubiquitin ligase activity |
| NM_002598 | Programmed cell death 2, tv-1 | PDCD2 | 6q27 | Ubiquitous | Cytoplasm | Apoptosis and regulation of cell proliferation |
| NM_003685 | KH-type splicing regulatory protein (FUSE binding protein 2) | KHSRP | 19p13.3 | Nervous system | Nucleus | Neurone specific splicing of the N1 exon of SRC; assembly of other proteins |
| NM_015399 | Breast cancer metastasis suppressor 1 | BRMS1 | 14q13.1 | Brain | Unknown | – |
| NM_0314122 | GABA(A) receptor associated protein-like 1 | GABARAPL1 | 12p12.3 | Ubiquitous | Unknown | – |