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. 1999 Aug 3;96(16):8925–8930. doi: 10.1073/pnas.96.16.8925

Figure 4.

Figure 4

The protease domain of Gla-domainless fVIIa (a) and fVIIasTF (b, PDB code 1dan). The majority of the domain is shown in space-filling representation. The d-Phe-Phe-Arg inhibitor (orange), the N-terminal region Ile-153–Gly-156 {16–19} (red), and Met-306 {164} (yellow) are drawn in stick representation. The N-linked carbohydrate moiety observed in the GD-fVIIa structure is colored blue, and the serine protease activation domain (Gly-285–Ala-294 {142–152}, Gly-331–Gly-342 {184–193}, and Gly-365–Gly-372 {216–223}; ref. 25) is colored gray. The region encompassing Thr-307–Pro-321 {165–170I} is depicted as a red string and schematically shows the local secondary structure. A region of TF (Glu-91–Asn-96) that interacts with the protease domain around Met-306 {164} is shown in green (b). The red dotted line schematically represents the unmodeled region (Arg-315–Lys-316) of the GD-fVIIa structure. This figure was generated by using quanta (Molecular Simulations, Waltham, MA).