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. 2007 Jan 15;21(2):206–220. doi: 10.1101/gad.406207

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Copyright © 2007, Cold Spring Harbor Laboratory Press

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Figure 3. — Telomerase deficiency accelerates UV-induced carcinogenesis in K5TRF2/Terc^−/− mice compared with K5TRF2 controls. (A) Total number of papillomas per mouse in K5TRF2 mice after chronic UVB irradiation. (B) Number of carcinomas per mouse in K5TRF2 mice after chronic UVB irradiation. (C) Number of carcinomas per mouse in K5TRF2/Terc^−/− mice after chronic UVB irradiation. (D) Survival curve of chronically irradiated K5TRF2/Terc^−/− and K5TRF2 cohorts. All irradiated K5TRF2/Terc^−/− mice were dead at week 26 after the start of the treatment due to large skin tumors, while control K5TRF2 mice showed longer survival. The statistical significance of differences in survival using the log rank test is indicated. (E) Percentage of K5TRF2/G1Terc^−/− and K5TRF2 mice showing the indicated skin lesions at time of death after full histopathological analysis. Of notice, 100% of K5TRF2/Terc^−/− mice presented SCC lesions at the time of death.