Table 2.

Effect estimates (odds ratios) for spina bifida-affected pregnancies associated with CHKA SNPs hCV1562388 (A>C) and hCV1562393(C>G), PCYT1A SNPs rs939883 (T>A) and rs3772109 (T>C), California 1989–1991. OR: odds ratio; aOR: adjusted odds ratio by maternal ethnicity; CI: confidence interval.

CHKA gene	Cases (%)	Controls (%)	OR (95% CI)	aOR (95% CI)
SNP hCV1562388 (A>C)
AA	54 (54.0)	138 (41.2)	Reference	-
AC	38 (38.0)	154 (46.0)	0.63 (0.39–1.01)	0.62 (0.39–1.00)
CC	8 (8.0)	43 (12.8)	0.48 (0.21–1.08)	0.48 (0.21–1.10)
AC+CC	46 (46.0)	197 (58.8)	0.60 (0.38–0.94)	0.55(0.38–0.99)
SNP hCV1562393(C>G)
CC	66 (67.3)	225 (67.6)	Reference	-
CG+GG	32 (32.6)	108 (32.4)	0.99 (0.61–1.62)	1.01 (0.62–1.66)
PCYT1A gene	Cases (%)	Controls (%)	OR (95% CI)	aOR (95% CI)
SNP rs939883 (T>A)
TT	35 (34.3)	132 (39.9)	Reference	-
TA	48 (47.1)	161 (48.6)	1.12 (0.69–1.84)	1.14 (0.70–1.87)
AA	19 (18.6)	38 (11.5)	1.89(0.97–3.67)	1.85 (0.95–3.61)
SNP rs3772109 (T>C)
TT	33 (33.7)	104 (31.2)	Reference	-
TC	51 (52.0)	164 (49.2)	0.98 (0.59–1.62)	0.99 (0.60–1.65)
CC	14 (14.3)	65 (19.5)	0.68 (0.34–1.36)	0.69 (0.34–1.41)